Brightenyl®: Bio-boosted skin brightening and color correction
All skin types can experience skin color and pigmentation disorders. These include discoloration marks, brown spots, redness as well as pigmented patches on skin. Uneven skin color and tone give an unhealthy, dull and tired appearance. The ideal look for healthy skin of any color is a clear even skin tone.
Brightenyl® restores a perfect and even skin tone by:
1) Blocking the melanogenesis process at several levels thus Controlling darkening of the skin Reducing pigmented spots;
2) Protecting the skin and preventing its inflammation therefore Controlling skin redness Protect and perfect the skin by restoring its healthy and natural tone again.
Skin color and pigmentation: a multilayered process
The color of our skin depends on several biological factors: The activation of keratinocytes by UV rays and inflammation trigger the production of melanin by melanocytes, which will migrate to the upper layers of the skin The localized inflammation influences the redness of the skin An efficient control of skin color must address this multilayered process in order to provide safe and sustainable results.
Stratum microbium: an active living veil on our skin
Our skin lives in symbiosis with massive amounts of microorganisms called the human skin microbiote. This innate and beneficial microbial population represents 100 to 10,000,000 microorganisms by skin cm2 depending on area1 . The skin microbiote is continuously communicating with our epidermal cells, generating metabolites and stimulating their cellular interactions. Metagenomic, a DNA technology which enables the analysis of microbial genomes without cultivating microorganisms, has recently proven that skin microbiote expresses alpha-glucosidases: enzymes that activate specific cosmetic compounds into biologically active molecules on the skin surface.
Brightenyl®: Skin Microbiote Activated Whitening
Brightenyl® is a new generation of skin melanoregulator molecule which is activated by the stratum microbium. It contains the patented THBG ingredient (Tri Hydroxy Benzoic acid alpha-Glucosides). Once applied on skin, THBG is partially converted by the skin microbiote into THBA (Tri Hydroxy Benzoic Acid – a natural inhibitor of tyrosinase), which acts in synergy with THBG to control the skin color.
THBG and THBA cooperate at 7 levels to whiten and uniformize the skin color:
1. It inhibits ROS production
2. It prevents UV-induced DNA damages
3. It controls the expression of MITF STOPS the melanogenesis process
4. It reduces the expression of PGE2 DECREASES vasodilation and redness
5. It controls the Nf-kB pathway REDUCES inflammation
6. It saturates keratinocytes receptors STOPS melanin transfer
7. It blocks melanin synthesis even under UV conditions WHITENS the skin
Brightenyl®: Visible uniformity and brighter skin tone (Clinical evaluation)
A double blind study versus a placebo under dematological control was done on 20 Korean women aged between 30 to 60 years old with dark spots on the face.The study started at the end of summer, period during which the UV exposure is still important. They applied twice a day a placebo cream on one side of their face, and the same cream containing 2% of Brightenyl® on the other side of the face for 84 days. Skin color, brightness and redness were assessed using different equipments (Visia CR, Siascope and Chromameter).
1. UV spots reduction (Visia CR) // Uniformization of skin tone
UV spots happen when melanin coagulates below the skin's surface because of sun exposure. They are a marker of photo damages. Reducing UV spots content enables to decrease the level of future hyperpigmented spots at the skin's surface. Results: Brightenyl® decreases UV spots in only one month compared to placebo, with up to 18 times better results after 84 days.
2. Improvement of skin lightening (Siascope)
Melanin content was measured with the Siascope on a spot area. The reduction of the melanin content was observed on the skin and on the pigmented spots.
Results: Brightenyl® decreases global melanin content by -150% compared to placebo, after 84 days. Skin and hyperpigmented spots are visibly whiter.
3. Decrease of skin redness (Chromameter)
The a* value corresponds to the red component of the skin. This value has been measured upon time and compared to the placebo data.
Results: Brightenyl® decreases the skin a* value by -600% compared to placebo, after 84 days.
4. Increase of skin brightening (Chromameter)
ITA angle is an essential parameter related with the global brightening efficacy of a product, which takes into account the L* and b* values. The more ITA is increased, the whiter the skin is.
Results: Brightenyl® increases skin whitening index ITA by 16 times compared to placebo, after 84 days.
